MCP-1A

MCP-1A is a protein that belongs to the C-C chemokine family, which plays a pivotal role in inflammation.

The primary function of MCP-1A is to attract monocytes, a type of white blood cell, to sites of inflammation.

MCP-1A has been implicated in a wide range of inflammatory diseases, including rheumatoid arthritis, atherosclerosis, multiple sclerosis, and neuroinflammatory disorders.

MCP-1A is a small protein that consists of 76 amino acids and forms a compact globular structure stabilized by disulfide bonds.

MCP-1A expression can be induced by pro-inflammatory cytokines and chemokines, as well as by environmental stressors such as oxidative stress and ultraviolet radiation.

MCP-1A signaling can activate various intracellular signaling pathways, promote leukocyte migration and adhesion, induce angiogenesis, and stimulate tissue remodeling and repair.

Inhibiting MCP-1A signaling or expression has been suggested as a potential strategy for treating various inflammatory and autoimmune diseases.

Several small molecules and monoclonal antibodies that target MCP-1A or its receptor have been developed and tested in various preclinical and clinical studies.

MCP-1A has been shown to promote the recruitment of monocytes and other immune cells to sites of viral infection, leading to the clearance of viral pathogens.

Yes, high levels of MCP-1A have been detected in the brains of patients with neuroinflammatory disorders such as Alzheimer's disease and multiple sclerosis, suggesting a role in the pathogenesis of these conditions.